FusionPlex
RNA NGS Library construction
ArcherDX FusionPlex is a targeted next-generation sequencing (NGS) research product that powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect fusions in a single sequencing product, even without prior knowledge of fusion partners or breakpoints. (RUO product)
Find More Unknown Fusions
Compared with traditional NGS sequencing methods, FusionPlex™ can detect more novel fusions. Taking the NTRK gene fusion as an example, traditional NGS mutations can only detect known mutational breakpoints. Archer AMP technology can detect all known and unknown NTRK gene fusions, which is the method with the highest detection rate. The lyophilized reagent can greatly reduce the human error, and make clinicians identify more variants that related with cancer-target therapy.
Comprehensive Fusion Detection
AMP chemistry utilizes open-ended targeted amplification to identify gene fusions whether or not the fusion partner is known.
Splice Variants
Detect cancer-associated isoforms and alternative splicing events.
Low Input
Purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.
Customized Design
Customize this panel by adding any of our functionally-tested designs. Invitae’s Assay Marketplace lets you browse our catalog of targeted AMP chemistry-based panels, modify an existing panel with additional targets, or create a new panel that fits your exact requirements.
FusionPlex Solid Tumor Panels
| FusionPlex Panel | input | 定序資料量 | 分析基因總數 |
|---|---|---|---|
| ALK RET ROS1 v2 | RNA | - | 3 |
| Lung | RNA | 500k | 14 |
| Oncology Research | RNA | 3M | 75 |
| Sarcoma | RNA | 1.5M | 26 |
| Solid Tumor | RNA | 3M | 53 |
| Thyroid and Lung | RNA | 1.5M | 36 |
FusionPlex Blood cancer Panels
| FusionPlex Panel | input | 定序資料量 | 分析基因總數 |
|---|---|---|---|
| ALL | RNA | 1.5 M | 81 |
| Heme v2 | RNA | 1.5 M | 87 |
| Lymphoma | RNA | 2 M | 125 |
| Myeloid | RNA | 1.5 M | 84 |
| Pan-Heme | RNA | 4.5 M | 199 |
FusionPlex-Simple, Lyophilized Workflow
- Lyophilized reagents reduces the manual operation time of NGS library to 2.5 hours
- The procedure is simpler and faster than other NGS library construction, and it is ready for sequencing within 9 hours
- FusionPlex technology is suitable for Illumina and Ion Torrent sequencing platforms
- Built for wide sample types such as frozen tissue and FFPE samples
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