FusionPlex

RNA NGS Library construction

ArcherDX FusionPlex is a targeted next-generation sequencing (NGS) research product that powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect fusions in a single sequencing product, even without prior knowledge of fusion partners or breakpoints. (RUO product)

Find More Unknown Fusions

Compared with traditional NGS sequencing methods, FusionPlex™ can detect more novel fusions. Taking the NTRK gene fusion as an example, traditional NGS mutations can only detect known mutational breakpoints. Archer AMP technology can detect all known and unknown NTRK gene fusions, which is the method with the highest detection rate. The lyophilized reagent can greatly reduce the human error, and make clinicians identify more variants that related with cancer-target therapy.

Comprehensive Fusion Detection

AMP chemistry utilizes open-ended targeted amplification to identify gene fusions whether or not the fusion partner is known.

Splice Variants

Detect cancer-associated isoforms and alternative splicing events.

Low Input

Purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.

Customized Design

Customize this panel by adding any of our functionally-tested designs. Invitae’s Assay Marketplace lets you browse our catalog of targeted AMP chemistry-based panels, modify an existing panel with additional targets, or create a new panel that fits your exact requirements.

FusionPlex Solid Tumor Panels

FusionPlex Panel	input	定序資料量	分析基因總數
ALK RET ROS1 v2	RNA	-	3
Lung	RNA	500k	14
Oncology Research	RNA	3M	75
Sarcoma	RNA	1.5M	26
Solid Tumor	RNA	3M	53
Thyroid and Lung	RNA	1.5M	36

FusionPlex Blood cancer Panels

FusionPlex Panel	input	定序資料量	分析基因總數
ALL	RNA	1.5 M	81
Heme v2	RNA	1.5 M	87
Lymphoma	RNA	2 M	125
Myeloid	RNA	1.5 M	84
Pan-Heme	RNA	4.5 M	199

FusionPlex-Simple, Lyophilized Workflow

Lyophilized reagents reduces the manual operation time of NGS library to 2.5 hours
The procedure is simpler and faster than other NGS library construction, and it is ready for sequencing within 9 hours
FusionPlex technology is suitable for Illumina and Ion Torrent sequencing platforms
Built for wide sample types such as frozen tissue and FFPE samples
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